Translation technique and textual studies in the Old Greek and Theodotion versions of Daniel.

This thesis focuses on two separate, but related areas: the analysis of translation technique and the Greek texts of Daniel. Foremost in the research of Translation Technique (TT) in the Septuagint is the need for a model that is appropriate for the analysis of different ancient languages. In recent years there has been an increasing emphasis on the features of literalism in a translation, but it is argued in this thesis that the focus on literalism is inadequate as a methodology for the analysis of TT. The contention of this thesis is that the analysis of TT should incorporate insights from modem linguistic research. Therefore, the main purpose of this thesis is to develop and apply such a model to the Old Greek (CG) and Theodotion (Th)versions of Daniel. The existence of two complete Greek versions of the book of Daniel that are closely related to the same Vorlage (at least in chapters 1-3 and 7-12), furnish ideal examples for the application of the methodology. Unfortunately, it is no straightforward matter to employ the OG of Daniel, because the available critical edition can no longer be regarded as reliable. The most important witness to the OG version of Daniel is Papyrus 967, and large portions of this manuscript have been published since the appearance of the critical edition of the OG of Daniel in 1954. Therefore, in order to analyze and compare the two Greek texts of Daniel, it is necessary to evaluate all of the variants of Papyrus 967 in order to establish a preliminary critical text of OG. Once a critical text is established the proposed methodology for translation technique is applied to selected passages in the OG and Th versions of Daniel. An analysis and comparison of TT in OG and Th makes it possible to: 1) characterize the TT employed by OG and Th in detail; 2) determine Th's relationship to OG, i.e. is it a revision or independent translation; 3) demonstrate how the Greek texts can be employed effectively for textual criticism of the Hebrew Bible. On the basis of the analysis of Th's text it is also possible to determine Th's relationship to the body of works, which exhibit a close formal correspondence to the Masoretic text, known as Kaige-Theodotion

A COMPARATIVE STUDY OF THE DEFENSE SYNDROMES OF SOME NEW ZEALAND MARINE CRUSTACEA

Five sympatric species of intertidal decapod crustaceans were studied in the field and laboratory with regard to the mechanisms used for predator defense. The species are sympatric and represent a gradient from high intertidal ( Cyclograpsus lavauxi ) to subtidal ( Notomithrax ursus ) with Petrolisthes elongatus , Heterozius rotundifrons , and Halicarcinus innominatus intermediate in tidal distribution. We tested the hypothesis that the diversity of defensive features would increase along a tidal gradient from high to low tide. All species were scored in the field for degree of background matching in color and tendency to autotomize appendages. In the laboratory individuals were scored with regard to delay to first movement following disturbance, maximum speed of movement, maximum extent of cheliped extension, and responses to conspecific alarm odors. Maximum sizes for individuals of the different species were obtained from the published literature. The five species varied significantly in the scores recorded for all of the different defensive features. Halicarcinus innominatus matched its background significantly better, Petrolisthes elongatus autotomized the most readily, Heterozius rotundifrons showed the longest periods of immobility following disturbance, Cyclograpsus lavauxi could move the fastest, and Notomithrax ursus reached the largest size. However, all species utilized multiple mechanisms related to predator avoidance. Summation of the rank scores for the seven different features revealed that the magnitude of the overall diversity of defensive features (1) did not vary along the tidal gradient and (2) showed surprisingly little variation among the different species. ___TAGSTART___BR___TAGEND___Cinq espèces sympatriques de crustacés décapodes intertidaux ont été étudiées sur le terrain et au laboratoire quant aux mécanismes utilisés pour la défense contre les prédateurs. Les espèces sont sympatriques et représentent un gradient de l'intertidal supérieur ( Cyclograpsus lavauxi ) au subtidal ( Notomithrax ursus ) avec Petrolisthes elongatus, Heterozius rotundifrons et Halicarcinus innominatus intermédiaire dans la répartition tidale. Nous avons testé l'hypothèse que la diversité des traits défensifs augmenterait suivant un gradient tidal, de la haute à la basse mer. Toutes les espèces étaient notées sur le terrain sur leur capacité à s'adapter à la couleur du milieu et la tendance à autotomiser des appendices. En laboratoire, les individus ont été notés sur le délai jusqu'au premier mouvement suivant la perturbation, la vitesse maximale du mouvement, l'extension maximale du chélipède, et les réponses aux odeurs d'alarmes spécifiques. Les tailles maximales des individus des différentes espèces ont été obtenues à partir des données publiées. Les cinq espèces différaient de façon significative dans les notes obtenues pour tous les traits de défense. Halicarcinus innominatus s'adapte le mieux au fond, de façon significative, Petrolisthes elongatus s'autotomise le plus facilement, Heterozius rotundifrons a montré les plus longues périodes d'immobilité après une perturbation, Cyclograpsus lavauxi se déplace le plus vite, et Notomithrax ursus a atteint la plus grande taille. Cependant, toutes les espèces ont utilisé des mécanismes multiples pour éviter les prédateurs. La somme des notes relatives aux sept différents critères ont révélé que l'échelle de diversité totale des critères de défense (1) ne variait pas suivant le gradient tidal et (2) montrait une variation étonnamment faible entre les différentes espèces.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43663/1/10613_2004_Article_brill_0011216x_v73n8_s1.pd

Educational and health outcomes of children treated for type 1 diabetes: Scotland-wide record linkage study of 766,047 children

Objective: This study was conducted to determine the association between childhood type 1 diabetes and educational and health outcomes. Research Design and Methods: Record linkage of nine Scotland-wide databases (diabetes register, dispensed prescriptions, maternity records, hospital admissions, death certificates, annual pupil census, school absences/exclusions, school examinations, and unemployment) produced a cohort of 766,047 singleton children born in Scotland who attended Scottish schools between 2009 and 2013. We compared the health and education outcomes of schoolchildren receiving insulin with their peers, adjusting for potential confounders. Results: The 3,330 children (0.47%) treated for type 1 diabetes were more likely to be admitted to the hospital (adjusted hazard ratio [HR] 3.97, 95% CI 3.79–4.16), die (adjusted HR 3.84, 95% CI 1.98–7.43), be absent from school (adjusted incidence rate ratio [IRR] 1.34, 95% CI 1.30–1.39), and have learning difficulties (adjusted odds ratio [OR] 1.19, 95% CI 1.03–1.38). Among children with type 1 diabetes, higher mean HbA1c (particularly HbA1c in the highest quintile) was associated with greater absenteeism (adjusted IRR 1.75, 95% CI 1.56–1.96, P < 0.001), increased school exclusion (adjusted IRR 2.82, 95% CI 1.14–6.98), poorer attainment (adjusted OR 3.52, 95% CI 1.72–7.18), and higher risk of unemployment (adjusted OR 2.01, 95% CI 1.05–3.85). Conclusions: Children with type 1 diabetes fare worse than their peers in respect of education and health outcomes, especially if they have higher mean HbA1c. Interventions are required to minimize school absence and ensure that it does not affect educational attainment

Standing together for reproducibility in large-scale computing: report on reproducibility@XSEDE

This is the final report on reproducibility@xsede, a one-day workshop held in conjunction with XSEDE14, the annual conference of the Extreme Science and Engineering Discovery Environment (XSEDE). The workshop's discussion-oriented agenda focused on reproducibility in large-scale computational research. Two important themes capture the spirit of the workshop submissions and discussions: (1) organizational stakeholders, especially supercomputer centers, are in a unique position to promote, enable, and support reproducible research; and (2) individual researchers should conduct each experiment as though someone will replicate that experiment. Participants documented numerous issues, questions, technologies, practices, and potentially promising initiatives emerging from the discussion, but also highlighted four areas of particular interest to XSEDE: (1) documentation and training that promotes reproducible research; (2) system-level tools that provide build- and run-time information at the level of the individual job; (3) the need to model best practices in research collaborations involving XSEDE staff; and (4) continued work on gateways and related technologies. In addition, an intriguing question emerged from the day's interactions: would there be value in establishing an annual award for excellence in reproducible research? Overvie

Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections.

The virus-host relationship in simian immunodeficiency virus (SIV) infected chimpanzees is thought to be different from that found in other SIV infected African primates. However, studies of captive SIVcpz infected chimpanzees are limited. Previously, the natural SIVcpz infection of one chimpanzee, and the experimental infection of six chimpanzees was reported, with limited follow-up. Here, we present a long-term study of these seven animals, with a retrospective re-examination of the early stages of infection. The only clinical signs consistent with AIDS or AIDS associated disease was thrombocytopenia in two cases, associated with the development of anti-platelet antibodies. However, compared to uninfected and HIV-1 infected animals, SIVcpz infected animals had significantly lower levels of peripheral blood CD4+ T-cells. Despite this, levels of T-cell activation in chronic infection were not significantly elevated. In addition, while plasma levels of β2 microglobulin, neopterin and soluble TNF-related apoptosis inducing ligand (sTRAIL) were elevated in acute infection, these markers returned to near-normal levels in chronic infection, reminiscent of immune activation patterns in 'natural host' species. Furthermore, plasma soluble CD14 was not elevated in chronic infection. However, examination of the secondary lymphoid environment revealed persistent changes to the lymphoid structure, including follicular hyperplasia in SIVcpz infected animals. In addition, both SIV and HIV-1 infected chimpanzees showed increased levels of deposition of collagen and increased levels of Mx1 expression in the T-cell zones of the lymph node. The outcome of SIVcpz infection of captive chimpanzees therefore shares features of both non-pathogenic and pathogenic lentivirus infections.This work was supported by the Biotechnology and Biological Sciences Research Council and by the Wellcome Trust.This is the final version of the article. It first appeared from PLOS via http://dx.doi.org/10.1371/journal.ppat.100514

The iPlant Collaborative: Cyberinfrastructure for Plant Biology

The iPlant Collaborative (iPlant) is a United States National Science Foundation (NSF) funded project that aims to create an innovative, comprehensive, and foundational cyberinfrastructure in support of plant biology research (PSCIC, 2006). iPlant is developing cyberinfrastructure that uniquely enables scientists throughout the diverse fields that comprise plant biology to address Grand Challenges in new ways, to stimulate and facilitate cross-disciplinary research, to promote biology and computer science research interactions, and to train the next generation of scientists on the use of cyberinfrastructure in research and education. Meeting humanity's projected demands for agricultural and forest products and the expectation that natural ecosystems be managed sustainably will require synergies from the application of information technologies. The iPlant cyberinfrastructure design is based on an unprecedented period of research community input, and leverages developments in high-performance computing, data storage, and cyberinfrastructure for the physical sciences. iPlant is an open-source project with application programming interfaces that allow the community to extend the infrastructure to meet its needs. iPlant is sponsoring community-driven workshops addressing specific scientific questions via analysis tool integration and hypothesis testing. These workshops teach researchers how to add bioinformatics tools and/or datasets into the iPlant cyberinfrastructure enabling plant scientists to perform complex analyses on large datasets without the need to master the command-line or high-performance computational services

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead